GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6479891 | 1 | rs4747045 | chr10:64926482 | NRBF2 | chr10:64893007-64914785:+ | 0.28 | 4.71 | 3.22E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs4747241 | 1 | rs4747241 | chr10:74036429 | ASCC1 | chr10:73856278-73976892:- | 0.19 | 3.45 | 0.000618 | Heschl's gyrus morphology |
| THCA | cis | rs4747241 | 1 | rs4747241 | chr10:74036429 | DNAJB12 | chr10:74092588-74114907:- | 0.21 | 5 | 8.17E-7 | Heschl's gyrus morphology |
| THCA | cis | rs4747241 | 1 | rs4747242 | chr10:74037193 | ASCC1 | chr10:73856278-73976892:- | 0.18 | 3.36 | 0.00084 | Heschl's gyrus morphology |
| THCA | cis | rs4747241 | 1 | rs4747242 | chr10:74037193 | DNAJB12 | chr10:74092588-74114907:- | 0.21 | 4.82 | 1.91E-6 | Heschl's gyrus morphology |
| THCA | cis | rs477692 | 1 | rs4750759 | chr10:131436603 | MGMT | chr10:131265454-131565783:+ | -0.37 | -11.28 | 2.44E-26 | Response to temozolomide |
| THCA | cis | rs7927771 | 1 | rs4752797 | chr11:47874364 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.22 | 2.61E-7 | Subjective well-being |
| THCA | cis | rs7927771 | 1 | rs4752856 | chr11:47648042 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.22 | 2.61E-7 | Subjective well-being |
| THCA | cis | rs7927771 | 1 | rs4752857 | chr11:47655752 | C1QTNF4 | chr11:47611216-47615961:- | -0.31 | -5.49 | 6.49E-8 | Subjective well-being |
| THCA | cis | rs7927771 | 1 | rs4752873 | chr11:47857520 | C1QTNF4 | chr11:47611216-47615961:- | -0.31 | -5.36 | 1.31E-7 | Subjective well-being |
| THCA | cis | rs3136441 | 1 | rs4752931 | chr11:46762516 | ZNF408 | chr11:46722368-46727461:+ | -0.19 | -3.63 | 0.000313 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4752932 | chr11:46773354 | DDB2 | chr11:47236493-47260769:+ | 0.23 | 3.54 | 0.000434 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4752932 | chr11:46773354 | ZNF408 | chr11:46722368-46727461:+ | -0.18 | -3.55 | 0.000421 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4752933 | chr11:46803785 | DDB2 | chr11:47236493-47260769:+ | 0.22 | 3.48 | 0.000544 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4752933 | chr11:46803785 | ZNF408 | chr11:46722368-46727461:+ | -0.19 | -3.61 | 0.000338 | HDL cholesterol |